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The list of grants:
DP1092640 Prof TP Davis; Dr CA Boyer
Polymer Stabilized and Bio-functionalised Metal Nanoparticles As Potential Vectors for Drug Therapies
2010 : $ 130,000
2011 : $ 130,000
2012 : $ 140,000
The project aims to make novel nanoparticles (extremely small, nano means one billionth of a metre) that carry medicines to very specific sites of the body and then release them. This would result in much improved outcomes for conventional chemotherapy but may also allow new gene therapies where diseases can be silenced at their source.
DP1093343 A/Prof PB Setterlund
Controlled/living radical polymerization in environmentally friendly miniemulsions induced by compressed carbon dioxide for synthesis of nanoparticles and well-defined polymer...
2010 : $ 110,000
2011 : $ 93,955
2012 : $ 95,000
Controlled/living radical polymerization is a technique for precise synthesis of polymer by radical polymerization, which has revolutionized polymer synthesis in terms of accessible polymer structures. However, controlled/living radical polymerization has yet to gain a strong foothold in industry mainly due to problems associated with its implementation in (aqueous) dispersed systems. The present Proposal addresses this key challenge by a novel environmentally friendly and versatile method for aqueous miniemulsion preparation by use of compressed carbon dioxide. Controlled/living radical polymerization in dispersed systems generates polymeric nanoparticles, which are of importance in many advanced and emerging technologies.
DP1092661 A/Prof M Stenzel; Dr G Chen; Dr DL Morris; Dr MH Pourgholami
Core-shell nanoparticle from polymers with pendant cyclodextrins
2010 : $ 140,000
2011 : $ 120,000
2012 : $ 110,000
A better drug delivery system will be developed for the treatment of cancer with albendazole. These nanoparticles enhance the circulation time in the body, but also facilitate the delivery of the drug to the site of the tumour, which ill increase the efficacy of the treatment. The nanoparticles are obtained by processing polymers with pendant cyclodextrin groups, which are a type of complex sugars. Aim of this work is the exploration of synthetic routes to generate nanoparticles. Tailoring the underpinning polymer structure of these nanoparticles will allow the optimisation of the release of albendazole from the drug carrier, thus improving cancer treatment.
DP1092694 A/Prof M Stenzel
Triggering the release of polymer bound platinum drugs
2010 : $ 110,000
2011 : $ 110,000
2012 : $ 110,000
Platinum drugs are found to be highly efficient as anti-cancer drugs. Their side-effects however, limit their application. Nanoparticles are developed that bind the platinum drug tightly as long as the drug circulates in the blood stream, but releases the drug as soon as it reaches the tumour. To treat prostate cancer, the nanoparticle will be attached to a targeting moiety - a monoclonal antibody - that facilitates the effective delivery to the prostate cancer cells, but leaves healthy cells unaffected. This proposal aims to develop suitable synthetic pathway to enhance the treatment of cancer by using appropriate delivery vehicles.
http://www.arc.gov.au/ncgp/dp/dp_outcomes.htm
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